The Antibiotic research group at Uppsala University was started in the 1980s. In the early papers we used different animal models to define the relation between serum and tissue concentrations of antibiotics. Later the focus was shifted towards the study of pharmacodynamic parameters, such as the post-antibiotic effects in vitro and in vivo with different methods. Our group described the post-antibiotic sub MIC effect, which has since been recognized as an important pharmacodynamic parameter with potential implications for dosage regimens.
Our research later mainly focused on pharmacokinetic/pharmacodynamic interactions of antibiotics using static and kinetic time-kill experiments to evaluate the antibacterial effects in terms of killing and emergence of resistance. In recent years we have focused on exploring the potential of antibiotic combinations in the treatment of multidrug-resistant Gram-negative bacteria using automated methods and methods for rapid determination of antibiotic susceptibilities.
Our primary objective is to generate in vitro data that are clinically relevant and can be used to guide the choice of appropriate drugs and dosing regimens for patients infected with multidrug-resistant bacteria.